Abstract: Nutritional optic neuropathy (NON) is a dysfunction of the optic nerve caused by nutritional deficiencies or metabolic disorders. It is primarily characterized by progressive bilateral and painless loss of central visual acuity associated with malnutrition or poor eating habits. There are also certain risk factors make the patient more susceptible to optic neuropathy including long-term smoking, alcohol abuse, chronic diarrhea and bariatric surgery. It is widely accepted that the pathogenesis of NON are dominated by the theory of mitochondrial dysfunction. Oxidative stress damage and axon demyelination also play important roles in the development of the disease.

Key words: nutritional optic neuropathy, nutritional deficiencies, vitamin, metal